The Hirsch Lab works on Adeno-Associated Virus (AAV) biology and the development AAV Gene Therapeutics.
- Synthetic Inverted Terminal Repeats…We have a panel of rationally designed ITRs that alter nearly all aspects of AAV vector biology including production, transduction efficiency, and the cellular responses to the vector
- AAV vectors and “Helper” viruses…The evolved relationship of AAV with other viruses is down right intriguing, and offers clues about AAV vector optimization towards safer more efficient therapeutic strategies
- Regulation of Transgenic Gene Expression…The community needed this one yesterday
- Anterior Eye Therapeutics…AAV vector applications in the anterior eye have been largely overlooked, we are addressing that deficit towards improved vision in patients with a variety of ocular diseases
- Muscle Therapeutics…In particular, we are investigating a potential AAV therapeutic for the treatment of dysferlinopathy